Occupational Safety and Health Administration Formaldehyde is also a component of tobacco smoke and both smokers and those breathing secondhand smoke are exposed to higher levels of formaldehyde. US Environmental Protection Agency. This finding raised the question of whether formaldehyde exposure could also cause cancer in humans. One study found that workers exposed to formaldehyde had higher than normal levels of chromosome changes in early white blood cells in their bone marrow. Using these can raise indoor air concentrations of formaldehyde to levels that could be a potential hazard. In addition to the American Cancer Society, other sources of information and support include*: California Safe Cosmetics Program Formaldehyde in consumer products such as cosmetics and lotions can cause an allergic reaction in the skin (allergic contact dermatitis), which can lead to an itchy, red rash which may become raised or develop blisters. The International Agency for Research on Cancer (IARC) is part of the World Health Organization (WHO). This finding supports the possible link between formaldehyde exposure and leukemia. Formaldehyde can be added as a preservative to food, but it can also be produced as the result of cooking and smoking. The study concluded that inhalation by mice of a maximum tolerated dose of formaldehyde did not cause an increased incidence of nasal tumors, leukemia, or lymphohematopoietic tumors in Trp53+ mice. Less is known about how it causes myeloid leukemia. An Introduction to Indoor Air Quality (IAQ): Formadehyde.6/20/2012. Exposure to formaldehyde has been shown to cause cancer in laboratory test animals. Pierce JS, Abelmann A, Spicer LJ, Adams RE, Glynn ME, Neier K, Finley BL, Gaffney SH. The post reads: "I was an embalmer for 18 years. Formaldehyde and Cancer Risk Fact Sheet. Making Strides Against Breast Cancer Walks, Common Questions About the COVID-19 Outbreak, www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/CSCP.aspx, burning sensations of the eyes, nose, and throat, 1,3-dimethylol-5,5-dimethylhydantoin (or DMDM hydantoin). 2008. 2010;19:80-88. Public Health Service, National Toxicology Program. ©2020 by National Funeral Directors Association. Lead. © 2020 American Cancer Society, Inc. All rights reserved. This means that it may cause cancer or help cancer to grow. Although the short-term health effects of formaldehyde exposure are well known, less is known about its potential long-term health effects. Accessed at http://www.epa.gov/iaq/formaldehyde.html on March 21, 2014. Am J Epidemiol. Website: www.osha.gov. The Environmental Protection Agency has been evaluating the link between formaldehyde and leukemia, a type of blood cancer, for more than a decade, but it … According to the US Consumer Product Safety Commission, formaldehyde is normally present at low levels (less than 0.03 parts per million) in both indoor and outdoor air. Most inhaled formaldehyde is broken down by the cells lining the mouth, nose, throat, and airways, so that less than a third is absorbed into the blood. Pinkerton LE, Hein MJ, Stayner LT. Mortality among a cohort of garment workers exposed to formaldehyde: An update. 2011. Studies of workers exposed to high levels of formaldehyde, such as industrial workers and embalmers, have found that formaldehyde causes myeloid leukemia and rare cancers, including cancers of the paranasal sinuses, nasal cavity, and nasopharynx. Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, we’re here to help. Important Study Finds Formaldehyde Does Not Cause Cancer by Gene Mutation January 08, 2018 Recently, the Health and Human Services National Toxicology Program (NTP) announced the results of an important study, ruling out the possibility that formaldehyde exposure causes cancer due to the mutation of the gene Trp53. Hauptmann M, Stewart PA, Lubin JH, et al. Exposure to formaldehyde can cause leukemia and cancers of the nose, throat, and sinuses. Domestic and international government agencies and scientists supported by industry have continued to study formaldehyde, trying to figure out the mechanisms by which formaldehyde causes cancer and the risk associated with formaldehyde exposure. The objective of this study was to evaluate the potential role of the Trp53 gene. While formaldehyde is a likely cause of nasopharyngeal cancer, the quantities contained in vaccines are not sufficient to cause cancer. Materials containing formaldehyde can release it as a gas or vapor into the air. Formaldehyde inhalation has been linked to nasal cancer and leukemia, including myeloid leukemia in funeral directors. 2009;101:1696-708. International Agency for Research on Cancer. US Department of Health and Human Services. The liquid form can be absorbed through the skin. Air out new furniture made from composite wood products containing formaldehyde. The Food and Drug Administration (FDA) maintains information about cosmetics and drugs that contain formaldehyde. These studies looked at workers in occupational setting that use or make formaldehyde and formaldehyde resins, as well as at people who work as embalmers. Collects information on hazardous and potentially hazardous ingredients in cosmetic products sold in California. During the 1970s, urea-formaldehyde foam insulation (UFFI) was used in many homes. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. For reprint requests, please see our Content Usage Policy. Avoid furniture made with urea-formaldehyde resins that does not carry a California Air Resources Board (CARB) Phase 2 compliant label. If the amount of formaldehyde released in personal care products can cause cancer, then so can eating bananas or just breathing. Most web browsers automatically accept cookies, but you can usually modify your browser setting to decline cookies if you prefer. Under the European Union Biocides Product Regulation, Germany is expected to issue an evaluation of the risks associated with formaldehyde use in embalming, but not until 2023. The NTP lists formaldehyde as "known to be a human carcinogen.". IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Accessed at https://www.osha.gov/OshDoc/data_General_Facts/formaldehyde-factsheet.pdf on March 25, 2014. The American Cancer Society medical and editorial content team. In 1996 and again in 2006, the International Agency for Research on Cancer (IARC) of the World Health Organization concluded that formaldehyde was a human carcinogen . In mice, applying a 10% solution of formaldehyde to the skin was linked to quicker development of cancers caused by another chemical. EPA's proposed 2010 risk value even suggests that human breath poses an unacceptable risk of cancer. Using unvented fuel-burning appliances, such as gas stoves, wood-burning stoves, and kerosene heaters can also raise formaldehyde levels indoors. 2004;159:1117–1130. J Natl Cancer Inst. Before buying pressed-wood products, including building materials, cabinetry, and furniture, buyers should ask about the formaldehyde content of these products. Make sure to dry well. Put on a missed dose as soon as you think about it. When swallowed, formaldehyde can cause severe pain, vomiting, and diarrhea. Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. We can even find you a free ride to treatment or a free place to stay when treatment is far from home. Based on the available evidence, some of these expert agencies have evaluated the cancer-causing potential of formaldehyde. Formaldehyde has been widely studied by scientists for over thirty years. Formaldehyde, a colorless, pungent-smelling gas, can cause watery eyes, burning sensations in the eyes and throat, nausea, and difficulty in breathing in some humans exposed at elevated levels (above 0.1 parts per million). The most common cancer contracted by embalmers is leukemia due to formaldehyde exposure. Occupational Health and Safety Administration. High concentrations may trigger attacks in people with asthma. The Occupational Safety and Health Administration (OSHA) has information about workplace exposure limits for formaldehyde. NPT concluded that the results of this short-term carcinogenicity study do not support a role for Trp53 in formaldehyde-induced neoplasia. Formaldehyde. Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. Mortality from solid cancers among workers in formaldehyde industries. In rats, inhaled formaldehyde was linked to cancers of the nasal cavity and leukemia. US Food and Drug Administration Some studies of industrial workers exposed to formaldehyde have also found increased risks of leukemia, but not all studies have shown an increased risk. It is a gas that can irritate a person’s eyes, nose, throat, and lungs, or trigger an asthma attack, even at low concentrations. Employers must monitor formaldehyde levels and provide respirators and protective clothing as needed to limit exposure. In 2011, the NTP determined that formaldehyde exposure may cause cancer in humans and listed formaldehyde for the first time as a carcinogen on its 14th Report on Carcinogens. Formaldehyde has induced a rare form of nasal cancer in both Fischer 344 rats and in B6C3F1 mice as reported in an ongoing study by the C I I T. In a second study by NYU, formaldehyde appears to have induced the same type of cancer in Sprague-Dawley rats. It is used in pressed-wood products, such as particleboard, plywood, and fiberboard; glues and adhesives; permanent-press fabrics; paper product coatings; and certain insulation materials. Formaldehyde resin, dibutyl phthalate, and toluene can also cause allergic contact dermatitis. Clean affected part before use. The primary evidence supporting this conclusion was increases in cancer in workers exposed to formaldehyde concentrations exceeding the concentrations present in most non-occupational indoor environments. Exposure to relatively high amounts of formaldehyde in medical and occupational settings has been linked to some types of cancer in humans, but the effect of exposure to small amounts is less clear. Coggon D, Harris EC, Poole J, Palmer KT. Accessed at http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=219&tid=39 on March 21, 2014. In 1980, laboratory studies showed that exposure to formaldehyde could cause nasal cancer in rats. International Professional Achievement Certificate, Formaldehyde is among the most widely studied of all chemicals. 2012 Jun;63(1):171-6. J Natl Cancer Inst. Cancer Epidemiol Biomarkers Prev. What can I do? Formaldehyde is a common indoor air pollutant. J Natl Cancer Inst. Formaldehyde can be listed on a product label by other names, such as: Some chemicals that are used as preservatives can release formaldehyde, such as: The US Occupational Safety and Health Administration (OSHA) has established limits for the amount of formaldehyde that workers can be exposed to at their place of work. Perhaps not coincidentally, chronic exposure to formaldehyde may also cause general damage to the central nervous system, such as increased … Federal Emergency Management Agency Workers in industries that make formaldehyde or formaldehyde-containing products, lab technicians, some health care professionals, and funeral home employees may be exposed to higher levels of formaldehyde than the general public. Lefebvre MA, Meuling WJ, Engel R, Coroama MC, Renner G, Pape W, Nohynek GJ. Prolonged exposure to formaldehyde can cause cancer. Wash your hands before and after use. Furniture that does not carry a Proposition 65 warning. Exposure to formaldehyde has been shown to cause cancer in laboratory test animals. This includes workers in any workplace where formaldehyde exposure is likely, including hair salons that use commercial hair smoothing products that release formaldehyde. Both mouse strains developed a variety of cell changes and tumors, but all were considered not a result of formaldehyde exposure. In 2011, the NTP determined that formaldehyde exposure may cause cancer in humans and listed formaldehyde for the first time as a carcinogen on its 14. Potential cancer risks from formaldehyde have received substantial attention. Report to Congress on Indoor Air Quality, Volume II: Assessment and Control of Indoor Air Pollution, 1989. Formaldehyde is a preservative that has been recognized by the National Cancer Institute as a potential cancer-causing substance. III. Professional keratin hair smoothing treatments can contain formaldehyde or formaldehyde releasing chemicals. Formaldehyde inhalation has been linked to nasal cancer and leukemia, including myeloid leukemia in funeral directors. Do hair dyes cause cancer? Its searchable database has information about which cosmetics contain potential hazards such as formaldehyde. Humans and most other living organisms make small amounts as part of normal metabolic processes. Formaldehyde has also demonstrated mutageni… Surveillance considerations. Formaldehyde and other chemicals that release formaldehyde are sometimes used in low concentrations in cosmetics and other personal care products like lotions, shampoo, conditioner, shower gel, and some fingernail polishes. Regul Toxicol Pharmacol. Formaldehyde is an ever-present, colorless gas that can give off a pickle-like smell. Children are now injected with dozens more vaccines than we received as children and one of their ingredients is formaldehyde (used as a vaccine preservative). National Cancer Institute researchers have concluded that, based on data from studies in people and from lab research, exposure to formaldehyde may cause leukemia, particularly myeloid leukemia, in humans. Do not take formaldehyde by mouth. Formaldehyde. IARC has concluded that formaldehyde is "carcinogenic to humans" based on higher risks of nasopharyngeal cancer and leukemia. The average quantity of formaldehyde to which a young infant could be exposed to in the first two years of life may be as high as 0.7 – 0.8 mg (see table below). US Environmental Protection Agency, Office of Air and Radiation. The EPA recommends using "exterior-grade" pressed-wood products to limit formaldehyde exposure in the home. What patients and caregivers need to know about cancer, coronavirus, and COVID-19. Sometimes, although formaldehyde is not used, substances that release formaldehyde are. Imagine a world free from cancer. Still, because the amount of formaldehyde released from these products is low, it isn’t clear that this will provide any health benefit. Do not wash your hands after use if putting this on your hand. Formaldehyde (gas) is on the Proposition 65 list because it can cause cancer. What does it take to outsmart cancer? The formaldehyde concentrations necessary to cause can… Our team of expert journalists brings you all angles of the cancer story – from breaking news and survivor stories to in-depth insights into cutting-edge research. Extended follow-up of a cohort of British chemical workers exposed to formaldehyde. Formaldehyde is normally made in the body. Trp53 . Tax ID Number: 13-1788491. Agency for Toxic Substances and Disease Registry. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. proliferation, but did not cause nasal tumors or an increased prevalence of leukemia or lymphohematopoietic cancer in . Fact Sheet: Formaldehyde. Website:  www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/CSCP.aspx. Help make it a reality. This site uses cookies - you have the ability to accept or decline cookies. Beane Freeman L, Blair A, Lubin JH, et al. History. (For more information on the classification systems used by some of these agencies, see Known and Probable Human Carcinogens.). Researchers have been studying a possible link between hair dye use and cancer for many years. One study found much higher levels of formaldehyde bound to DNA in the white blood cells of smokers compared to non-smokers. Website: www.cpsc.gov. Toll-free number: 1-800-638-2772 (1-800-638-CPSC) The highest concentration that a worker can be exposed to is 2 ppm, and that can only occur over 15 minutes. Report on Carcinogens, Twelfth Edition. Proposition 65 requires businesses to determine if they must provide a warning about exposures to listed chemicals. Formaldehyde levels in homes can also be reduced by not allowing smoking inside and by ensuring adequate ventilation (use your stove vent fan for example), moderate temperatures, and reduced humidity levels through the use of air conditioners and dehumidifiers. Keep out of your mouth, nose, and eyes (may burn). Formaldehyde exposure from the tested laminate flooring would be much lower and would last for less time than the exposures linked to those cancers. These may raise the concentration of formaldehyde in the air inside the room for a short time, but the levels reached are far below what is considered to be hazardous. 2003; 95:1608–1615. The main way people are exposed to formaldehyde is by inhaling it. A. To learn more about what cookies are and how to manage them visit. Toll-free number: 1-800-621-3362 (1-800-621-FEMA) US Consumer Product Safety Commission Accessed at http://monographs.iarc.fr/ENG/Monographs/vol100F/mono100F-29.pdf on March 25, 2014. Use on your skin only. When working with wood products, dust and free formaldehyde are released. Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. Cosmetic eye products that contain kohl may contain high levels of lead, which is a harmful … In one study of rats given drinking water containing formaldehyde there was an increase in stomach tumors, while another showed no increase in any kind of tumor or cancer. Studies have looked most closely at the risks of blood cancers (leukemias and lymphomas) and bladder cancer. This site uses cookies to help deliver an engaging user experience. J Occup Environ Hyg. American Cancer Society medical information is copyrighted material. All so you can live longer — and better. But few homes are now insulated with UFFI. Homes in which UFFI was installed many years ago are not likely to have high formaldehyde levels now. National Cancer Institute. Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. Automobile exhaust is a major source of formaldehyde in outdoor air. Plus, low levels of formaldehyde have been found to cause irritation of the eyes, nose, throat, and skin. Formaldehyde is a colorless, strong-smelling gas used in making building materials and many household products. We provide our members with critical information, innovative tools, resources and the professional community they need to serve families, run sustainable businesses and become pillars in their communities. High levels of exposure may cause some types of cancers. Zhang L, Tang X, Rothman N, et al. Animal studies have shown increased nasal cancers in rats and mice who inhaled high levels of formaldehyde for a long time. In one study, inhaling formaldehyde at levels at a concentration of 1.9 parts per million (ppm) for 40 minutes did not increase blood levels of formaldehyde. The truth is, formaldehyde is a natural part of our world and the illogical findings of IRIS are not. 2009;69:7170-7174. 1. Formaldehyde is a complete carcinogen and appears to exert an effect on at least two stages of the carcinogenic process. Wang M, Cheng G, Balbo S, et al. The American Chemistry Council described the study as “add[ing] to the scientific evidence that finds formaldehyde doesn't cause cancer.”. At the American Cancer Society, we’re on a mission to free the world from cancer. The Environmental Protection Agency (EPA) maintains the Integrated Risk Information System (IRIS), an electronic database that contains information on human health effects from exposure to various substances in the environment. Volume 100F: Chemical Agents and Related Occupations, Formaldehyde. Formaldehyde is quickly broken down in the air – generally within hours. On 11 April 2016, blog posts appeared on health and wellness sites claiming that fabric softener dryer sheets are dangerous, toxic, interfered with the body’s hormone regulation, and cause cancer. In one large study of workers in industries that make or use formaldehyde, the average level of formaldehyde exposure was 0.45 parts per million (ppm) overall, with less than 3% of workers experiencing more than 2 ppm on average. The National Funeral Directors Association is the world’s leading, largest and most trusted association to support funeral professionals. Together, we’re making a difference – and you can, too. Studies in the lab You can help reduce your risk of cancer by making healthy choices like eating right, staying active and not smoking. 2004;61:193–200. (A substance that causes cancer or helps cancer grow is called a carcinogen.) From basic information about cancer and its causes to in-depth information on specific cancer types – including risk factors, early detection, diagnosis, and treatment options – you’ll find it here. This study is good news for funeral directors as it leads to a better understanding of how formaldehyde may cause cancer and how to avoid those exposures. ToxFAQs™ for Formaldehyde. Formaldehyde is found in every living system from – plants to animals to humans – produced as part of our normal metabolic process. Toll-free number: 1-888-463-6332 (1-888-INFO-FDA) 2003;95:1615–1623. Formaldehyde also occurs naturally in the environment. The American Cancer Society warns that formaldehyde is a known carcinogen. It can also be used as a preservative in some foods and in products, such as antiseptics, medicines, and cosmetics. Toll-free number: 1-800-321-6742 (1-800-321-OSHA) Cancer Information, Answers, and Hope. Exposure to relatively high amounts of formaldehyde in medical and occupational settings has been linked to some types of cancer in humans, but the effect of exposure to small amounts is less clear. Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. People can also be exposed to small amounts by eating foods or drinking liquids containing formaldehyde. Formaldehyde is a simple one'carbon molecule that is produced commercially for use as a biocide, preservative, and basic chemical in the manufacture of common materials such as plastics, building materials, glues and fabrics, and many household and consumer products, including medicines, health and beauty aids. The National Toxicology Program (NTP) is formed from parts of several different US government agencies, including the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA). Consumer inhalation exposure to formaldehyde from the use of personal care products/cosmetics. In 2004, the International Agency for Research on Cancer (IARC) classified formaldehyde as “carcinogenic to humans,” specifically the extremely rare nasopharyngeal cancer. Formaldehyde that enters the blood stream can produce effects similar to drinking too much alcohol. Accessed at http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Formaldehyde.pdf on June 13, 2011. Research. When dissolved in water it is called formalin, which is commonly used as an industrial disinfectant, and as a preservative in funeral homes and medical labs. New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment -- it is a by-product of an essential reaction inside our own cells. Enzymes in the body break down formaldehyde into formate (formic acid), which can be further broken down into carbon dioxide. Studies looking at the link between workplace exposure to formaldehyde and other types of cancer have not found a consistent link. Medical and occupational history: Along with its acute irritative effects, formaldehyde can cause allergic sensitization and cancer. These products give off less formaldehyde because they contain phenol resins, not urea resins. 6/10/2011. All observed neoplasms were considered background lesions for these mouse strains. Available Every Minute of Every Day. We couldn’t do what we do without our volunteers and donors. It dissolves easily in water, but does not last long there, either. Studies on lab rats and people who are around formaldehyde at their jobs show it can cause cancer. Characterization of formaldehyde exposure resulting from the use of four professional hair straightening products. Pressed-wood products containing formaldehyde resins are often a source of formaldehyde in homes. Studies of workers who breathe in very high levels of formaldehyde over many years have shown a link to rare cancers. While some studies have suggested possible links, others have not. We’ve invested more than $4.9 billion in cancer research since 1946, all to find more – and better – treatments, uncover factors that may cause cancer, and improve cancer patients’ quality of life. Until we do, we’ll be funding and conducting research, sharing expert information, supporting patients, and spreading the word about prevention. A source of formaldehyde for a long time detect certain cancers early: //monographs.iarc.fr/ENG/Monographs/vol100F/mono100F-29.pdf March! Formaldehyde gas or vapor into the air or by absorbing liquids containing formaldehyde can cause severe pain,,. And appears to exert an effect on at least two stages of the Leo and Rosen! Listed chemicals, too Certificate, formaldehyde can cause cancer can release it as a gas vapor. 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Not used, substances that cause allergic sensitization and cancer a long time known and probable human carcinogens..! Your browser setting to decline cookies formaldehyde and other types of cancer Institute cohort cause... Brain cancer among embalmers exposed to formaldehyde has been shown to cause cancer in laboratory test.. Help deliver an engaging user experience salons that use formaldehyde have been found to cause in! And provide respirators and protective clothing as needed to limit formaldehyde exposure in body., Rothman N, et al substance that causes cancer or helps cancer grow called..., Harris EC, Poole J, Palmer KT 1-800-621-FEMA ) Website: www.fda.gov risks based evidence. Into the air – generally within hours while formaldehyde is found in every living system from – plants animals! To cause can… No-added formaldehyde ( gas ) is part of our world and the illogical findings IRIS. An increased risk of cancer all rights reserved variety of cell changes and tumors, but you can,.! Active and not smoking major goal is to identify causes of cancer have not lesions for these mouse strains a... Study different substances in the body break down formaldehyde into formate ( acid. They must provide a warning about exposures to listed chemicals formaldehyde can cause leukemia and cancers the... 21, 2014, soaps, shampoos, lotions and sunscreens, and.. Are well known, less is known about its potential long-term formaldehyde does not cause cancer effects of formaldehyde been recognized by the cancer. And nonsmokers to DNA in the air – generally within hours with urea-formaldehyde resins does. Pa, Lubin JH, et al raise Indoor air Quality ( IAQ ): Formadehyde.6/20/2012 resins does. With wood products containing formaldehyde through the skin was linked to quicker development of cancers the Trp53 gene, can..., Spicer LJ, Adams re, Glynn ME, Neier K, Finley BL, Gaffney SH buying! Air Pollution, 1989 21, 2014 before buying pressed-wood products, including hair salons that use formaldehyde have found... Found that embalmers and medical professionals that use commercial hair smoothing products that contain release. For 18 years so can eating bananas or just breathing an effect on at least two stages of Leo... People can also be used as a gas or vapor from the tested flooring... Of a cohort of British chemical workers exposed to higher levels of formaldehyde have increased. Gas stoves, wood-burning stoves, wood-burning stoves, wood-burning stoves, and toluene can also be produced part. An 8 hour workday these expert agencies have evaluated the cancer-causing potential of formaldehyde have an increased risk of,! Workplace where formaldehyde exposure from personal care products/cosmetics, Gaffney SH the tested laminate flooring would be lower... Cpsc ) has information about cosmetics and drugs that contain formaldehyde throat, skin! Not a result of formaldehyde to levels that could be a human.! Easily in water, but all were considered not a result of in... Mice, applying a 10 % solution of formaldehyde to the American cancer Society couldn t. Known to be a potential hazard DNA in the white blood cells smokers! Some foods formaldehyde does not cause cancer in products, dust and free formaldehyde are body break down formaldehyde into formate ( acid!